Anisimova V A, Kopylov P K, Shemianin I G
State Scientific Center of Applied Microbiology, Obolensk.
Vestn Ross Akad Med Nauk. 1997(6):52-9.
The data available in the literature over the past decade as to the design and use of directly acting proteins in the treatment of a number of diseases are analyzed. The structure and functions of toxins inhibiting protein synthesis are reviewed. The structural and functional properties of conjugated and recombinant immunotoxins are compared and clinical findings are reviewed. Particular emphasis is laid on the requirements for such hybrid proteins. It is concluded that specific cell elimination as a principal approach to treating tumors, autoimmune and other diseases will find wide medical application just in the near future.
分析了过去十年文献中有关直接作用蛋白在多种疾病治疗中的设计和应用的数据。综述了抑制蛋白质合成的毒素的结构和功能。比较了缀合免疫毒素和重组免疫毒素的结构和功能特性，并综述了临床研究结果。特别强调了对此类杂合蛋白的要求。得出结论，作为治疗肿瘤、自身免疫性疾病和其他疾病的主要方法，特异性细胞清除将在不久的将来得到广泛的医学应用。
