Sparber S B, Nagasawa S, Burklund K E
Res Commun Chem Pathol Pharmacol. 1977 Nov;18(3):423-31.
Six daily injections (subacute) of 2.5 mg d-amphetamine/kg resulted in a 60% higher concentration of unchanged drug in adipose compared with adipose from rats injected once. Subacute treatment also resulted in 30% less amphetamine in brain one hour after injection, when the animals were killed for tissue analysis. Moderate stress, in the form of foot shock for fifteen minutes, terminating fifteen minutes prior to sacrifice, mobilized the drug from adipose and doubled brain levels of amphetamine in the subacute group. Brain levels in the group given a single dose of drug were unaltered by shock, but heart content of amphetamine was increased 30% as a result of shock. It is concluded that enhanced reactivity to some of the behavioral effects of amphetamine, upon repeated administration, may be due to cumulation of the drug in mobilizable pools.
每天注射（亚急性）2.5毫克右旋苯丙胺/千克，连续注射六天，与单次注射的大鼠相比，脂肪组织中未代谢药物的浓度高出60%。亚急性治疗还导致在注射后一小时动物被处死进行组织分析时，大脑中的苯丙胺减少30%。以足部电击15分钟的形式施加适度应激，在处死前15分钟结束，可使亚急性组脂肪组织中的药物动员起来，并使大脑中的苯丙胺水平增加一倍。单次给药组的大脑水平不受电击影响，但电击使心脏中的苯丙胺含量增加了30%。结论是，反复给药后对苯丙胺某些行为效应的反应性增强，可能是由于药物在可动员库中的累积所致。
