Hollinger M A, Giri S N, Freywald M
Res Commun Chem Pathol Pharmacol. 1977 Dec;18(4):689-96.
The purpose of this study was to determine if elevating lung zinc would prevent the lethal effect of paraquat. Several doses of zinc sulfate (20, 40, and 80 mg/kg) were administered intraperitoneally for 7 days and lung ainc measured. Only 80 mg/kg produced a significantly increase. Acute administration of 80 mg/kg zinc sulfate produced an 81% elevation in lung zinc within 4 hr. Animals were treated with zinc sulfate (80 mg/kg) followed 4 hr later by paraquat (42.5 mg/kg). They also received 2 additional doses of zinc during the next 48 hr. Zinc treated animals were not protected against the lethal effect of paraquat but, instead, had a higher fatality rate than animals treated with paraquat alone.
本研究的目的是确定提高肺锌含量是否能预防百草枯的致死作用。腹腔注射几种剂量的硫酸锌（20、40和80毫克/千克），持续7天，并测量肺锌含量。只有80毫克/千克的剂量能使肺锌含量显著增加。急性给予80毫克/千克硫酸锌在4小时内可使肺锌含量升高81%。动物先接受硫酸锌（80毫克/千克）治疗，4小时后再给予百草枯（42.5毫克/千克）。在接下来的48小时内，它们还额外接受了2剂锌。用锌治疗的动物并未免受百草枯致死作用的影响，相反，其死亡率高于仅用百草枯治疗的动物。
