Hollinger M A, Zuckermann J E, Giri S N
Res Commun Chem Pathol Pharmacol. 1978 Aug;21(2):295-305.
The effect of acute and chronic paraquat administration on rat lung collagen was studied. A single dose of paraquat (35 mg/kg, ip) produces a transient increase in lung collagen synthesis within the first several days. In animals sacrificed 18 days later, there is insignificant accumulation of collagen (9%). Three injections of paraquat (25 mg/kg) spaced at weekly intervals produces a 31% increase in lung collagen by the middle of the fourth week. In view of the technical difficulties involved with the use of paraquat as a pulmonary fibrotic agent in the rat, search for an alternative model is suggested.
研究了急性和慢性给予百草枯对大鼠肺胶原蛋白的影响。单次给予百草枯（35毫克/千克，腹腔注射）在最初几天内会使肺胶原蛋白合成短暂增加。在18天后处死的动物中，胶原蛋白积累不显著（9%）。每周间隔注射三次百草枯（25毫克/千克），到第四周中期时肺胶原蛋白增加31%。鉴于在大鼠中使用百草枯作为肺纤维化剂存在技术困难，建议寻找替代模型。
