Brown L A, Losos G J
Res Vet Sci. 1977 Sep;23(2):196-203.
Using 90 albino rats, a comparison was made between the response to experimental infections of Trypanosoma brucei and T congolense of approximately three weeks duration by observation of parasitaemia, packed cell volume values, post mortem spleen and lymph weights, and histology of thymus, spleen, lymph nodes and bone marrow. In T congolense infection, phagocytosis of trypanosomes in the spleen appeared to be the main response of the host's haemopoietic tissues to the parasites, which were observed only intravascularly. In T brucei infection immunological responses occurred in the spleen and lymph nodes in addition to trypanosome phagocytosis. Trypanosomes were seen intercellularly in thymus, mediastinal tissue and lymph node sinuses and parasitaemia reached considerably higher values than in T congolense infection. Erythrophagocytosis in the spleen was the only histological feature which could account for the reduction in packed cell volume which occurred near death in both infections, medullary haemopoiesis being increased. Changes in the thymus, incorporating plasma cell production and depletion of cortical small lymphocytes, occurred in both infections.
利用90只白化大鼠，通过观察寄生虫血症、红细胞压积值、死后脾脏和淋巴结重量以及胸腺、脾脏、淋巴结和骨髓的组织学，对约三周时间内布氏锥虫和刚果锥虫实验感染的反应进行了比较。在刚果锥虫感染中，脾脏中锥虫的吞噬作用似乎是宿主造血组织对寄生虫的主要反应，寄生虫仅在血管内被观察到。在布氏锥虫感染中，除了锥虫吞噬作用外，脾脏和淋巴结还发生了免疫反应。在胸腺、纵隔组织和淋巴结窦中可见细胞间的锥虫，寄生虫血症的值比刚果锥虫感染时高得多。脾脏中的红细胞吞噬作用是唯一能解释两种感染接近死亡时红细胞压积降低的组织学特征，骨髓造血增加。两种感染均出现胸腺变化，包括浆细胞产生和皮质小淋巴细胞减少。
