Martinotti M G, Forni M, Del Monte A M, Giovarelli M, Forni G, Landolfo S
Boll Ist Sieroter Milan. 1981;60(4):288-96.
Pathological findings in various organs and tissues, T and B lymphocyte inability to proliferate towards several mitogens, and the appearance of serum interferon at progressive stages after intraperitoneal infection of BALB/c mice with Trypanosoma brucei brucei are reported. Heavy parasitaemia is evident throughout infection and complete hyporesponsiveness is already present on day 3. A sharp interferon production peak appears after 48 hours. The anatomopathological picture makes it clear that infection is substantially restricted to the blood. Secondary involvement of liver, lung and kidney takes the form of perivascular cuffs. These appear at relatively early stages. By contrast, spleen and lymph nodes appear to be greatly altered.
报告了用布氏布氏锥虫腹腔感染BALB/c小鼠后，各器官和组织的病理发现、T和B淋巴细胞对几种有丝分裂原的增殖无能以及在疾病进展阶段血清干扰素的出现。在整个感染过程中寄生虫血症严重，在第3天就已出现完全无反应性。48小时后出现干扰素产生的尖锐峰值。解剖病理学图像表明感染主要局限于血液。肝脏、肺和肾脏的继发性受累表现为血管周围套袖状浸润，这些在相对早期阶段出现。相比之下，脾脏和淋巴结似乎有很大改变。
