Bissonnette J M, Wickham W K
Respir Physiol. 1977 Nov;31(2):161-8. doi: 10.1016/0034-5687(77)90099-8.
In unanesthetized pregnant guinea pigs 5-7 ml of maternal blood which had been equilibrated with carbon monoxide (CO) was reinfused into the sow's carotid artery. Three serial blood samples were withdrawn from the sow and a single terminal fetal sample obtained for determination of CO content and hemoglobin concentration. Transplacental CO uptake (VCO) was determined as the product of fetal blood CO content and fetal CO space (11.8% of fetal weight). Placental diffusing capacity (DPCO) was calculated by dividing VCO by the mean partial pressure difference between maternal and fetal blood. DPCO (ml-min(-1)/torr) increased significantly with gestational age: 45-50 days = 0.0413, 51-57 days = 0.1092 and 58-68 days = 0.1858. This increase paralleled fetal weight but was not related to placental weight.
在未麻醉的怀孕豚鼠中，将5 - 7毫升已用一氧化碳（CO）平衡过的母体血液重新注入母猪的颈动脉。从母猪身上采集了三份连续的血样，并获取了一份胎儿终末血样，用于测定CO含量和血红蛋白浓度。经胎盘的CO摄取量（VCO）通过胎儿血CO含量与胎儿CO容量（胎儿体重的11.8%）的乘积来确定。胎盘扩散能力（DPCO）通过将VCO除以母体和胎儿血液之间的平均分压差来计算。DPCO（毫升·分钟⁻¹/托）随着胎龄显著增加：45 - 50天 = 0.0413，51 - 57天 = 0.1092，58 - 68天 = 0.1858。这种增加与胎儿体重平行，但与胎盘重量无关。
