Bacon B J, Gilbert R D, Kaufmann P, Smith A D, Trevino F T, Longo L D
Placenta. 1984 Nov-Dec;5(6):475-87. doi: 10.1016/s0143-4004(84)80002-8.
To determine the relation of placental structure to placental diffusing capacity (DPCO), we exposed Hartley guinea pigs to 12 or 14 per cent O2 from day 15 of gestation to near term (64 days). At that time we measured DPCO and fetal body and placental weights. In addition, we used stereological techniques to measure placental parameters important to diffusing capacity. We also used a mathematical model with results from the stereological measurements to predict the diffusing capacity. In the first hypoxic group (E1), measured DPCO decreased 10.1 +/- 3.7 per cent, while that predicted was 2.4 per cent less than control. Total vascular volume decreased 6.6 +/- 3.6 per cent, while tissue volume and mean diffusion distance increased 10.2 +/- 5.6 per cent and 12.9 +/- 7.0 per cent, respectively. In the pair-fed animals, measured DPCO decreased 22.6 +/- 4.6 per cent, while that predicted was 20.0 per cent less than control. There were no significant stereological differences in this group. In the second (E2) hypoxic group, measured DPCO increased 27.2 +/- 7.4 per cent, while that predicted increased 38.2 per cent. For this same group, total vascular volume increased 11.7 +/- 3.0 per cent, and tissue volume and mean diffusion distance decreased 18.2 +/- 4.6 per cent and 17.8 +/- 3.8 per cent, respectively. These results demonstrate the dependence of placental diffusing capacity upon placental structure.
为了确定胎盘结构与胎盘弥散能力（DPCO）之间的关系，我们从妊娠第15天至接近足月（64天），将哈特利豚鼠暴露于含12%或14%氧气的环境中。在那时，我们测量了DPCO、胎儿体重和胎盘重量。此外，我们使用体视学技术测量对弥散能力重要的胎盘参数。我们还使用了一个基于体视学测量结果的数学模型来预测弥散能力。在第一个低氧组（E1）中，测量的DPCO下降了10.1±3.7%，而预测值比对照组低2.4%。总血管容积下降了6.6±3.6%，而组织容积和平均弥散距离分别增加了10.2±5.6%和12.9±7.0%。在配对喂养的动物中，测量的DPCO下降了22.6±4.6%，而预测值比对照组低20.0%。该组在体视学上没有显著差异。在第二个低氧组（E2）中，测量的DPCO增加了27.2±7.4%，而预测值增加了38.2%。对于同一组，总血管容积增加了11.7±3.0%，组织容积和平均弥散距离分别下降了18.2±4.6%和17.8±3.8%。这些结果证明了胎盘弥散能力对胎盘结构的依赖性。
