Doganov N, Dimitrov R, Marinov B, Shtereva K, Nachev A, Bozhilov D, Blagoeva V
Akush Ginekol (Sofiia). 1997;36(1):11-3.
The study presents the results from the use of cefotetan for perioperative prophylaxis in 43 gynaecology patients compared with 29 controls without perioperative antibiotic prophylaxis with similar diseases and operations. Both groups show equal percentage of the cases with smooth postoperative period (70 and 72% respectively). 13 of the patients on cefotetan prophylaxis received additional antibiotic treatment (9 because of temperature up to 37.5 degrees and 4 because of temperature from 37.6 to 38.5 degrees). Mo major infections postoperative complications occurred among the patients on cefotetan prophylaxis. 8 of the non-prophylacted patients needed antibiotic treatment postoperatively including 4 with temperature above 38.5 degrees. Two infections of the operative wounds also occurred in the same group. The conclusion is that cefotetan effectively prevents the major infection postoperative complications in gynaecology. The administration of additional antibiotic treatment is most often not warranted.
该研究展示了43例妇科患者使用头孢替坦进行围手术期预防的结果,并与29例患有相似疾病且接受相同手术但未进行围手术期抗生素预防的对照组患者进行了比较。两组术后恢复顺利的病例百分比相同(分别为70%和72%)。接受头孢替坦预防的13例患者接受了额外的抗生素治疗(9例因体温高达37.5度,4例因体温在37.6至38.5度之间)。接受头孢替坦预防的患者中未发生重大感染术后并发症。8例未进行预防的患者术后需要抗生素治疗,其中4例体温高于38.5度。同一组中还发生了2例手术伤口感染。结论是头孢替坦可有效预防妇科重大感染术后并发症。通常无需进行额外的抗生素治疗。