Carothers A D
MRC Human Genetics Unit, Western General Hospital, Edinburgh, U.K.
Biometrics. 1997 Sep;53(3):848-56.
A general approach is described for efficiently and objectively analyzing comparative genomic hybridization (CGH) profile data based on the use of realistic statistical models and the application of standard likelihood-based inference. In contrast to other methods in current use, the approach provides a most parsimonious explanation by identifying the smallest number of relative DNA copy number changes consistent with the data, together with estimates of their levels and positions and of their standard errors. By making efficient use of available data, it has the potential to enhance the resolution of CGH technology. The computational feasibility of the method is illustrated by application to real CGH profile data from human chromosome 4.
本文描述了一种基于现实统计模型的使用和基于标准似然推理的应用，对比较基因组杂交（CGH）图谱数据进行高效、客观分析的通用方法。与目前使用的其他方法不同，该方法通过识别与数据一致的最少数量的相对DNA拷贝数变化，以及对其水平、位置及其标准误差的估计，提供了最简洁的解释。通过有效利用现有数据，它有可能提高CGH技术的分辨率。通过应用于来自人类4号染色体的真实CGH图谱数据，说明了该方法的计算可行性。
