Sánchez-Solís de Querol M, Castillo-Ochando F, Díaz-Torres M, Sayed-Sancho N, Sánchez-Flores F, Pajarón de Ahumada M
Unidad de Neumología Pediátrica, Hospital Universitario Virgen de la Arrixaca, Murcia.
An Esp Pediatr. 1997 Jul;47(1):14-6.
The aim of this study was to evaluate ribavirin therapy for acute bronchiolitis caused by viral syncytial respiratory infection.
Ninety-seven patients with acute bronchiolitis in which respiratory syncytial virus was identified by direct immunofluorescence and admitted to the hospital between October 1990 and May 1995 were studied. Data pertaining to age, sex, weight, respiratory frequency at admission, respiratory frequency on the fourth day, day in which respiratory ausculation was normal, day in which there were no thoracic retractions, number of days that the infants needed oxygen, duration of hospital stay, and whether or not they were treated with ribavirin were collected retrospectively.
At admission there were no statistically significant differences in patients treated or not with ribavirin or in age, sex or weight, but the respiratory frequency was higher in those patients treated with ribavirin than in those who were not. The number of days of oxygen therapy was statistically different between these groups, with infants treated with ribavirin requiring oxygen for 2.7 days and the nontreated group requiring 1.7 days. However, we think that this difference is not clinically relevant.
We did not find any difference of clinical relevance between patients treated or not with ribavirin.
本研究旨在评估利巴韦林对由呼吸道合胞病毒感染引起的急性细支气管炎的治疗效果。
研究对象为1990年10月至1995年5月间因直接免疫荧光法检测出呼吸道合胞病毒而入院的97例急性细支气管炎患者。回顾性收集了有关年龄、性别、体重、入院时呼吸频率、第4天呼吸频率、呼吸听诊正常的日期、无胸廓凹陷的日期、婴儿吸氧天数、住院时间以及是否接受利巴韦林治疗的数据。
入院时，接受或未接受利巴韦林治疗的患者在年龄、性别或体重方面无统计学显著差异，但接受利巴韦林治疗的患者呼吸频率高于未接受治疗的患者。两组之间吸氧治疗天数有统计学差异，接受利巴韦林治疗的婴儿吸氧2.7天，未治疗组吸氧1.7天。然而，我们认为这种差异并无临床意义。
我们未发现接受或未接受利巴韦林治疗的患者之间存在任何具有临床意义的差异。
