透明质酸对干眼患者角膜上皮屏障功能的有效性
Effectiveness of hyaluronan on corneal epithelial barrier function in dry eye.
作者信息
Yokoi N, Komuro A, Nishida K, Kinoshita S
机构信息
Department of Ophthalmology, Kyoto Prefectural University of Medicine, Japan.
出版信息
Br J Ophthalmol. 1997 Jul;81(7):533-6. doi: 10.1136/bjo.81.7.533.
AIMS/BACKGROUND: The aim of this study was to assess quantitatively the effectiveness of hyaluronan on corneal disruption in patients with dry eye. Corneal epithelial barrier function was evaluated by measuring fluorescein permeability using a slit-lamp fluorophotometer.
METHODS
11 patients with dry eye were assigned to this study. Hyaluronan ophthalmic solution (0.1% hyaluronic acid) was instilled five times a day to the right eye, in addition to the usual artificial tear solutions. The left eye received only the artificial tear solutions. Corneal barrier function was evaluated on the pretreatment day, and at 2 and 4 weeks after treatment. Fluorophotometry was used to measure fluorescein uptake at the central and lower corneal portions.
RESULTS
Two weeks after treatment, hyaluronan treated right corneas showed significant corneal epithelial barrier improvement in the lower portion, compared with the pretreatment day (p < 0.025). Four weeks after treatment, the treated corneas showed significant improvement in the central corneal portion (p < 0.025) and improvement in the lower portion, compared with the pretreatment day. The untreated left corneas, on the other hand showed no improvement during the course of the study.
CONCLUSION
This study suggests that hyaluronan is effective in the treatment of corneal epithelial disruption in dry eye.
目的/背景：本研究旨在定量评估透明质酸对干眼症患者角膜损伤的疗效。使用裂隙灯荧光光度计测量荧光素通透性，以此评估角膜上皮屏障功能。
方法
11名干眼症患者参与本研究。除常规人工泪液外，透明质酸钠眼药水（0.1%透明质酸）每天滴入右眼5次。左眼仅使用人工泪液。在治疗前、治疗后2周和4周评估角膜屏障功能。使用荧光光度法测量角膜中央和下部的荧光素摄取量。
结果
治疗2周后，与治疗前相比，使用透明质酸治疗的右眼角膜下部的角膜上皮屏障有显著改善（p < 0.025）。治疗4周后，与治疗前相比，治疗的角膜中央部分有显著改善（p < 0.025），下部也有改善。另一方面，未治疗的左眼在研究过程中没有改善。
结论
本研究表明透明质酸对治疗干眼症角膜上皮损伤有效。
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