非洲加勒比裔患者术中使用海绵5-氟尿嘧啶的小梁切除术
Trabeculectomy with intraoperative sponge 5-fluorouracil in Afro-Caribbeans.
作者信息
Lachkar Y, Leyland M, Bloom P, Migdal C
机构信息
Western Eye Hospital, London.
出版信息
Br J Ophthalmol. 1997 Jul;81(7):555-8. doi: 10.1136/bjo.81.7.555.
AIM
To study the efficacy and safety of intraoperative 5-fluorouracil (5-FU) in Afro-Caribbean patients.
METHODS
The results of trabeculectomy in 18 eyes of 18 Afro-Caribbean patients in whom a sponge soaked in 25 mg/ml solution of 5-FU was applied between Tenon's capsule and sclera for 5 minutes before excision of the trabecula were compared with 16 eyes of 16 Afro-Caribbean patients matched for age, quantity, and duration of preoperative medications, who underwent trabeculectomy without 5-FU.
RESULTS
The mean postoperative intraocular pressure (IOP) at 1 month was 15.6 (SD 6.1) mm Hg in the 5-FU group and 18.0 (5.2) mm Hg in the control group (p = 0.15). There was no significant difference in the IOP at 6, 12, 15, 18, and 24 months in the two groups. Success rate at 18 months defined as an IOP less than or equal to 21 mm Hg with no adjunctive medication was 56% in the 5-FU group and 55% in the control group. No major complications were noted in either group.
CONCLUSION
Intraoperative sponge 5-FU alone is safe but does not appear to decrease the risk of failure of trabeculectomy in Afro-Caribbeans.
目的
研究术中使用5-氟尿嘧啶（5-FU）对非洲加勒比裔患者的疗效和安全性。
方法
将18例非洲加勒比裔患者的18只眼睛行小梁切除术的结果进行比较，这组患者在切除小梁前，于Tenon囊与巩膜之间放置浸泡于25mg/ml 5-FU溶液中的海绵5分钟；另一组为16例年龄、术前用药量及用药时间相匹配的非洲加勒比裔患者的16只眼睛，行小梁切除术但未使用5-FU。
结果
5-FU组术后1个月平均眼压（IOP）为15.6（标准差6.1）mmHg，对照组为18.0（5.2）mmHg（p = 0.15）。两组在6、12、15、18和24个月时的眼压无显著差异。18个月时的成功率定义为眼压小于或等于21mmHg且无需辅助用药，5-FU组为56%，对照组为55%。两组均未发现重大并发症。
结论
术中单独使用海绵5-FU是安全的，但似乎并不能降低非洲加勒比裔患者小梁切除术失败的风险。
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