Hitti J, Watts D H, Burchett S K, Schacker T, Selke S, Brown Z A, Corey L
Department of Obstetrics and Gynecology, University of Washington, Seattle, USA.
Am J Obstet Gynecol. 1997 Aug;177(2):450-4. doi: 10.1016/s0002-9378(97)70214-x.
Our purpose was to determine whether pregnant women infected with human immunodeficiency virus-1 have an increased risk of herpes simplex virus-2 seropositivity and herpes simplex virus reactivation at delivery.
Sixty women infected with human immunodeficiency virus and 8408 other patients who were delivered at the University of Washington between 1989 and 1995 had herpes simplex virus serologic determinations at delivery. Genital herpes simplex virus cultures were obtained for 48 (80%) of the human immunodeficiency virus-infected women and 5567 (66%) of the controls. Logistic regression was used to adjust for possible confounding factors.
Forty-five (75%) of human immunodeficiency virus-infected women and 2709 (32%) controls were seropositive for herpes simplex virus-2 (p < 0.0001). Eight percent of human immunodeficiency virus-infected women and 2% of controls had herpes simplex virus reactivation in labor (p < 0.05).
Infection with herpes simplex virus-2 is common among pregnant women infected with human immunodeficiency virus. Herpes simplex virus reactivation complicates labor in this group more often than in other obstetric patients. The role of herpes simplex virus in perinatal human immunodeficiency virus transmission warrants further study.
我们的目的是确定感染人类免疫缺陷病毒1型的孕妇在分娩时单纯疱疹病毒2型血清阳性和单纯疱疹病毒再激活的风险是否增加。
1989年至1995年在华盛顿大学分娩的60名感染人类免疫缺陷病毒的妇女和8408名其他患者在分娩时进行了单纯疱疹病毒血清学检测。对48名（80%）感染人类免疫缺陷病毒的妇女和5567名（66%）对照者进行了生殖器单纯疱疹病毒培养。采用逻辑回归分析来调整可能的混杂因素。
45名（75%）感染人类免疫缺陷病毒的妇女和2709名（32%）对照者单纯疱疹病毒2型血清阳性（p<0.0001）。8%感染人类免疫缺陷病毒的妇女和2%的对照者在分娩时有单纯疱疹病毒再激活（p<0.05）。
感染人类免疫缺陷病毒的孕妇中单纯疱疹病毒2型感染很常见。与其他产科患者相比，单纯疱疹病毒再激活使该组患者的分娩更复杂。单纯疱疹病毒在围产期人类免疫缺陷病毒传播中的作用值得进一步研究。
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