Hook E W, Cannon R O, Nahmias A J, Lee F F, Campbell C H, Glasser D, Quinn T C
Division of Infectious Diseases, Johns Hopkins University School of Medicine, Baltimore, MD 21205.
J Infect Dis. 1992 Feb;165(2):251-5. doi: 10.1093/infdis/165.2.251.
To determine if infection with herpes simplex virus (HSV) type 2 is associated with human immunodeficiency virus (HIV) type 1 infection among patients attending sexually transmitted diseases clinics, a case-control study was done on coded sera from 179 HIV-1-infected patients and 367 age-, race-, and gender-matched HIV-1-seronegative patients. Although only 13 (2.3%) of 546 patients had a history of genital herpes treatment, 72% and 56.6%, respectively, had serologic evidence of prior infection with HSV-1 and -2. HSV-1 antibody prevalence was similar among both patient groups; however, HSV-2 antibodies were more common among those infected with HIV-1. Among heterosexual men, 62.7% of those infected with HIV-1 had HSV-2 antibodies compared with 46.7% of those not infected (P less than .01). The HSV-2 seroprevalence among women with or without HIV infection was 78.1% and 57.7%, respectively (P less than .02). A history of intravenous drug use and a reactive serologic test for syphilis were each independently associated with HIV-1 infection in heterosexuals. These data suggest that the two most common causes of genital ulcerative disease in the United States, genital herpes and syphilis, may contribute to increased risk for HIV-1 infection among heterosexuals.
为了确定在性传播疾病诊所就诊的患者中，2型单纯疱疹病毒（HSV）感染是否与1型人类免疫缺陷病毒（HIV）感染相关，对179例HIV-1感染患者和367例年龄、种族和性别匹配的HIV-1血清阴性患者的编码血清进行了一项病例对照研究。虽然546例患者中只有13例（2.3%）有生殖器疱疹治疗史，但分别有72%和56.6%的患者有HSV-1和-2既往感染的血清学证据。两组患者中HSV-1抗体流行率相似；然而，HSV-2抗体在HIV-1感染者中更为常见。在异性恋男性中，62.7%的HIV-1感染者有HSV-2抗体，而未感染者为46.7%（P小于0.01）。有或无HIV感染的女性中HSV-2血清阳性率分别为78.1%和57.7%（P小于0.02）。静脉吸毒史和梅毒血清学检测阳性均与异性恋者的HIV-1感染独立相关。这些数据表明，美国生殖器溃疡性疾病最常见的两个病因，生殖器疱疹和梅毒，可能会增加异性恋者感染HIV-1的风险。
