HIV感染队列中的癌症发病率。HIV感染肺部并发症研究组。

Cancer incidence among an HIV-infected cohort. Pulmonary Complications of HIV Infection Study Group.

作者信息

Johnson C C, Wilcosky T, Kvale P, Rosen M, Stansell J, Glassroth J, Reichman L, Wallace J, Markowitz N, Thompson J E, Hopewell P

机构信息

Henry Ford Health Sciences Center, Division of Biostatistics and Research Epidemiology, Detroit, MI 48202, USA.

出版信息

Am J Epidemiol. 1997 Sep 15;146(6):470-5. doi: 10.1093/oxfordjournals.aje.a009300.

DOI:10.1093/oxfordjournals.aje.a009300

PMID:9290507

Abstract

Malignancies, particularly Kaposi's sarcoma and non-Hodgkin's lymphoma (NHL), are associated with human immunodeficiency virus (HIV) infection. Cancer incidence among 1,073 asymptomatic HIV-infected individuals from the Pulmonary Complications of HIV Infection Study cohort, persons from six states followed from 1988 to 1994, was examined. Total cancer incidence was 3.99/100 person-years; for Kaposi's sarcoma, incidence was 2.64 cases/100 person-years, and for NHL, it was 1.18 cases/100 person-years. Total cancer (n = 156 cases) was higher among nonblacks than among blacks (rate ratio = 2.8, 95% confidence interval 1.3-6.1), with similar results for Kaposi's sarcoma and NHL. The rate of lung cancer (n = 5) among white, homosexual/bisexual males was 0.18 per 100 person-years, suggesting a high risk of lung cancer.

摘要

恶性肿瘤，尤其是卡波西肉瘤和非霍奇金淋巴瘤（NHL），与人类免疫缺陷病毒（HIV）感染有关。对来自HIV感染肺部并发症研究队列的1073名无症状HIV感染者（1988年至1994年对六个州的人员进行随访）的癌症发病率进行了检查。总癌症发病率为3.99/100人年；卡波西肉瘤的发病率为2.64例/100人年，NHL的发病率为1.18例/100人年。非黑人中的总癌症（n = 156例）高于黑人（率比 = 2.8，95%置信区间1.3 - 6.1），卡波西肉瘤和NHL的结果相似。白人同性恋/双性恋男性中的肺癌发病率（n = 5）为每100人年0.18例，表明肺癌风险较高。