Lenny N, Westendorf J J, Hiebert S W
Department of Tumor Cell Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Mol Biol Rep. 1997 Aug;24(3):157-68. doi: 10.1023/a:1006859700409.
The coordinated production of all blood cells from a common stem cell is a highly regulated process involving successive stages of commitment and differentiation. From analyses of mice deficient in transcription factor genes and from the characterizations of chromosome breakpoints in human leukemias, it has become evident that transcription factors are important regulators of hematopoiesis. During myelopoiesis, which includes the development of granulocytic and monocytic lineages, transcription factors from several families are active, including AML1/CBF beta, C/EBP, Ets, c-Myb, HOX, and MZF-1. Few of these factors are expressed exclusively in myeloid cells; instead it appears that they cooperatively regulate transcription of myeloid-specific genes. Here we discuss recent advances in transcriptional regulation during myelopoiesis.
由共同干细胞协调产生所有血细胞是一个高度受调控的过程，涉及连续的定向分化阶段。通过对转录因子基因缺陷小鼠的分析以及对人类白血病中染色体断点的特征描述，已明显看出转录因子是造血作用的重要调节因子。在包括粒细胞和单核细胞系发育的髓系造血过程中，几个家族的转录因子都有活性，包括AML1/CBFβ、C/EBP、Ets、c-Myb、HOX和MZF-1。这些因子中很少有仅在髓系细胞中表达；相反，它们似乎协同调节髓系特异性基因的转录。在此我们讨论髓系造血过程中转录调控的最新进展。
