Stepanek J
Schweiz Med Wochenschr. 1977 Dec 10;107(49):1820-1.
Hypoxia and the hypercapnia were produced in anesthetized dogs by artificial respiration with appropriate gas mixtures, and a study was conducted of the effects of these conditions on various metabolic parameters, viz. catecholamines, renin activity, lactate, pyruvate, cortisol, non-esterified free fatty acids (FFA), and ammonia, in the plasma of the arterial blood. Hypercapnia caused a distinct increase in catecholamine concentrations, renin activity and ammonia, and a decrease in lactate and pyruvate; cortisol and FFA levels were only slightly altered. Hypoxia increased lactate, pyruvate and--though only to a slight extent--FFA, cortisol and NH3. The changes induced by hypercapnia were chiefly attributable to activation of the sympathico-adrenal system; those induced by hypoxia were not.
通过使用适当的气体混合物对麻醉犬进行人工呼吸来制造低氧和高碳酸血症，并研究这些条件对动脉血浆中各种代谢参数的影响，即儿茶酚胺、肾素活性、乳酸、丙酮酸、皮质醇、非酯化游离脂肪酸（FFA）和氨。高碳酸血症导致儿茶酚胺浓度、肾素活性和氨明显增加，乳酸和丙酮酸减少；皮质醇和FFA水平仅有轻微变化。低氧增加了乳酸、丙酮酸，以及——尽管程度轻微——FFA、皮质醇和NH3。高碳酸血症引起的变化主要归因于交感-肾上腺系统的激活；低氧引起的变化则并非如此。
