Nakashima T, Nakashima T, Masuda M, Komiyama S
Departments of Otorhinolaryngology, Faculty of Medicine, Kyushu University, Japan.
J Laryngol Otol. 1997 Jan;111(1):38-42. doi: 10.1017/s0022215100136382.
To investigate the relation between the clinicopathological findings, and the survival of patients with malignant tumours of the maxillary sinus, and the tumour's biological parameters, we examined the expression of p53 and bcl-2 and the number of silver-stainable nucleolar organizer regions (AgNORs) in 23 paraffin-embedded specimens from primary tumours. Fifteen of 23 (65 per cent) maxillary tumours expressed p53 and two of 23 (nine per cent) tumours expressed the bcl-2 gene product. The mean number of AgNORs per nucleus was 5.2 +/- 2.4. There was no relationship between the expression of p53 or bcl-2 and the patient's clinical course. In contrast, there was a statistically significant difference in the survival of patients with a high (> 6) number of AgNORs and patients with a low (< 6) number of AgNORs. These data suggest that the number of AgNORs may be useful in evaluating the prognosis of patients with malignant maxillary sinus tumours.
为了研究上颌窦恶性肿瘤患者的临床病理表现、生存率与肿瘤生物学参数之间的关系，我们检测了23例原发肿瘤石蜡包埋标本中p53和bcl-2的表达以及银染核仁组成区（AgNORs）的数量。23例上颌窦肿瘤中有15例（65%）表达p53，23例中有2例（9%）表达bcl-2基因产物。每个细胞核AgNORs的平均数量为5.2±2.4。p53或bcl-2的表达与患者的临床病程之间没有关系。相比之下，AgNORs数量多（>6）的患者与数量少（<6）的患者在生存率上存在统计学显著差异。这些数据表明，AgNORs数量可能有助于评估上颌窦恶性肿瘤患者的预后。
