Stangassinger M, Giesecke D
Arch Int Physiol Biochim. 1979 May;87(2):265-74. doi: 10.3109/13813457909070499.
Experiments with continuous infusion of [14C] isobutyrate and single injection of [3H] glucose were performed in two sheep under fed and fasted conditions in order to investigate the contribution of isobutyrate to glucose synthesis. The pool size, total entry and irreversible loss of glucose in the fed sheep were 2.8 mmol/kg0.75, 1.70 and 1.43 mmol/h per kg0.75. After 72-h fasting these parameters decreased about 40% but recycling of glucose carbon increased from 16 to 38% of the total entry rate. Isobutyrate infused intravenously at a rate of 3.5 mmol/h contributed to a minimum of 3-5% of glucose entry indicating that at least 40-60% of the infused isobutyrate was used for net glucose synthesis. The efficiency of the glucogenic and energetic use of isobutyrate as compared to propionate is discussed.
为了研究异丁酸盐对葡萄糖合成的贡献，在两只绵羊处于进食和禁食状态下进行了持续输注[14C]异丁酸盐和单次注射[3H]葡萄糖的实验。进食绵羊体内葡萄糖的池大小、总进入量和不可逆损失分别为2.8 mmol/kg0.75、1.70 mmol/h per kg0.75和1.43 mmol/h per kg0.75。禁食72小时后，这些参数下降了约40%，但葡萄糖碳的再循环从总进入率的16%增加到38%。以3.5 mmol/h的速率静脉输注异丁酸盐对葡萄糖进入的贡献至少为3 - 5%，这表明至少40 - 60%的输注异丁酸盐被用于净葡萄糖合成。文中还讨论了与丙酸盐相比，异丁酸盐在生糖和能量利用方面的效率。
