Sekkarie M A
Department of Internal Medicine, Bluefield Regional Medical Center and West Virginia University, USA.
Am J Kidney Dis. 1997 Sep;30(3):437-9. doi: 10.1016/s0272-6386(97)90291-2.
Patients with chronic renal failure are often on multiple medications and are at risk for the development of adverse effects from drug interactions. Two cases of torsades de pointes that followed the initiation of clarithromycin therapy in patients receiving long-term cisapride therapy are being reported. Elevated cisapride levels while on this combination with return to therapeutic range while on cisapride only was documented in one of the patients. The role of the inhibition of cytochrome P-4503A4 in the occurrence of the arrhythmia is discussed.
慢性肾衰竭患者通常服用多种药物，存在因药物相互作用而产生不良反应的风险。本文报告了2例在长期接受西沙必利治疗的患者中，加用克拉霉素治疗后发生尖端扭转型室速的病例。其中1例患者记录到，联合用药时西沙必利水平升高，而仅使用西沙必利时则恢复到治疗范围。本文还讨论了细胞色素P - 4503A4抑制在心律失常发生中的作用。
