Mahlberg K, Krootila K, Uusitalo R
Leiras Eye Research Laboratory, Turku, Finland.
J Cataract Refract Surg. 1997 Jul-Aug;23(6):878-82. doi: 10.1016/s0886-3350(97)80247-7.
To study the compatibility of combinations of antibiotics and steroids commonly used in anterior segment surgery.
Research Laboratory, Helsinki University, Finland.
Aggregate production in vitro and in vivo was studied for three injectable antibiotics (cefotaxime sodium, tobramycin sulfate, and gentamicin) and four corticosteroids (triamcinolone acetonide, methylprednisolone sodium succinate, methylprednisolone acetate, and dexamethasone sodium phosphate) using conventional and dark-field microscopy. Aggregate formation on collagen shields and subconjunctival aggregate formation of tobramycin sulfate in combination with methylprednisolone acetate or dexamethasone sodium phosphate was also studied.
Dexamethasone sodium phosphate (4 mg/mL) did not form aggregates with any of the three antibiotics tested. Cefotaxime sodium did not cause aggregates when 24 mg/mL of dexamethasone sodium phosphate was used both in vitro and in vivo or in association with collagen shields.
To avoid undesired side effects, such as epithelial sloughing and corneal edema after collagen shield application, antibiotics and steroids must be carefully selected.
研究眼前节手术中常用抗生素与类固醇的配伍情况。
芬兰赫尔辛基大学研究实验室。
使用常规显微镜和暗视野显微镜，研究了三种注射用抗生素（头孢噻肟钠、硫酸妥布霉素和庆大霉素）和四种皮质类固醇（曲安奈德、甲泼尼龙琥珀酸钠、醋酸甲泼尼龙和地塞米松磷酸钠）在体外和体内的聚集产生情况。还研究了硫酸妥布霉素与醋酸甲泼尼龙或地塞米松磷酸钠联合使用时在胶原膜上的聚集形成以及结膜下聚集形成情况。
地塞米松磷酸钠（4毫克/毫升）与所测试的三种抗生素中的任何一种均未形成聚集体。当在体外、体内或与胶原膜联合使用24毫克/毫升地塞米松磷酸钠时，头孢噻肟钠未引起聚集体形成。
为避免不良副作用，如应用胶原膜后上皮脱落和角膜水肿，必须谨慎选择抗生素和类固醇。
