Lee B L, Matoba A Y, Osato M S, Robinson N M
Cullen Eye Institute, Baylor College of Medicine, Houston, Texas 77030.
Am J Ophthalmol. 1992 Aug 15;114(2):212-5. doi: 10.1016/s0002-9394(14)73987-x.
The use of collagen shields soaked in various combinations of medications has been advocated to enhance drug delivery to the cornea. Recently, severe corneal toxicity associated with aggregate formation in mixtures of gentamicin and methylprednisolone prompted our study of the effect of drug concentration, pH, and temperature on the solubility of several antibiotic and corticosteroid formulations commonly used to treat ocular disease. Selected combinations of cefazolin, vancomycin, tobramycin, gentamicin, methylprednisolone, and dexamethasone were evaluated. Mixtures of tobramycin and vancomycin produced no precipitates, but many spheroid aggregates were seen when methylprednisolone and gentamicin were combined. Although the effects of precipitate formation on drug bioavailability and toxicity have not been fully determined, until such information is available, the use of combinations of drugs that remain in solution during administration is recommended.
有人主张使用浸泡在各种药物组合中的胶原盾来增强药物向角膜的递送。最近，庆大霉素和甲基强的松龙混合物中与聚集体形成相关的严重角膜毒性促使我们研究药物浓度、pH值和温度对几种常用于治疗眼部疾病的抗生素和皮质类固醇制剂溶解度的影响。对头孢唑林、万古霉素、妥布霉素、庆大霉素、甲基强的松龙和地塞米松的选定组合进行了评估。妥布霉素和万古霉素的混合物没有产生沉淀，但甲基强的松龙和庆大霉素混合时会出现许多球状聚集体。虽然沉淀形成对药物生物利用度和毒性的影响尚未完全确定，但在获得此类信息之前，建议使用给药期间保持溶液状态的药物组合。
