Cakmakli S, Ersöz S, Tuğ T, Karaayvaz M, Akgül H
Department of Surgical Oncology, University Hospital of Ankara, Turkey.
Acta Oncol. 1997;36(5):489-92. doi: 10.3109/02841869709001304.
The efficacy of intra-arterial infusion chemotherapy (IACT) as the first step in a combined modality therapy in the treatment of locally advanced breast cancer was evaluated in a prospective clinical study consisting of 18 patients, 15 with stage IIIB, and three with stage IV breast cancer. A combined chemotherapy using adriamycin, mitomycin C and 5-Fluorouracil were administered at 3-week intervals until sufficient regression was achieved. Objective response rate was 66.6%. Among the 14 patients who received IACT for induction, plus surgery, simultaneous adjuvant chemotherapy and radiotherapy, 7 were disease-free at a mean of 19.5 (range 4-42) months. Six patients developed various relapses at a mean of 20.6 (range 12-28) months. IACT was found to be quite effective in local control. The early systemic relapse continues to be a serious problem that needs further intervention.
在一项前瞻性临床研究中，对18例局部晚期乳腺癌患者（15例IIIB期和3例IV期乳腺癌患者）进行了评估，以确定动脉内灌注化疗（IACT）作为综合治疗第一步的疗效。使用阿霉素、丝裂霉素C和5-氟尿嘧啶进行联合化疗，每3周给药一次，直至达到充分缓解。客观缓解率为66.6%。在14例接受IACT诱导治疗，随后进行手术、同步辅助化疗和放疗的患者中，7例在平均19.5个月（范围4 - 42个月）时无疾病进展。6例患者在平均20.6个月（范围12 - 28个月）时出现各种复发。发现IACT在局部控制方面相当有效。早期全身复发仍然是一个需要进一步干预的严重问题。
