Koyama H, Nishizawa Y, Wada T, Kabuto T, Shiba E, Iwanaga T, Terasawa T, Wada A
Cancer. 1985 Aug 15;56(4):725-9. doi: 10.1002/1097-0142(19850815)56:4<725::aid-cncr2820560404>3.0.co;2-3.
A multidisciplinary treatment including intra-arterial infusion chemotherapy as an induction therapy was administered to 55 patients with locally advanced breast cancer. Intra-arterial chemotherapy conducted preoperatively produced marked responses in primary and lymph node lesions with 78% complete + partial response (CR + PR), subsequently permitting extended radical mastectomy. Histologic examination of resected specimens also revealed that 33% of the patients had no viable cancer cells remaining in their lesions. Five-year and 10-year survival rates were 57% and 41%, respectively, compared with 24% and 18%, respectively for the 17 patients of historic control. Patients showing better local responses to intra-arterial chemotherapy had longer survival time with less frequent local recurrences. Intra-arterial chemotherapy is an effective modality for the treatment of locally advanced breast cancer.
对55例局部晚期乳腺癌患者采用了包括动脉内灌注化疗作为诱导治疗的多学科治疗方法。术前进行的动脉内化疗使原发灶和淋巴结病灶产生了显著反应，完全缓解+部分缓解（CR+PR）率为78%，随后可行扩大根治性乳房切除术。对切除标本的组织学检查还显示，33%的患者病灶中没有残留存活癌细胞。5年和10年生存率分别为57%和41%，而历史对照的17例患者的5年和10年生存率分别为24%和18%。对动脉内化疗局部反应较好的患者生存时间更长，局部复发频率更低。动脉内化疗是治疗局部晚期乳腺癌的一种有效方法。
