el-Shaaer H M, Abdel-Aziz S A, Allimony H A, Ali U F, Abdel-Rahman R M
Department of Chemistry, Faculty of Education, Ain-Shams University, Roxy, Cairo.
Pharmazie. 1997 Aug;52(8):585-9.
In the search for new antimicrobial compounds, several new sulfur bearing heterobicyclic moieties (4-11) have been synthesized by acylation and alkylation of acetamide, thioacetamide and semicarbazide derivatives. The structure of the products was deduced from elemental analyses as well as spectral data (IR, 1H NMR and MS). Significant antimicrobial activities were obtained for all new compounds especially against Fusarium oxysporum.
在寻找新型抗菌化合物的过程中，通过乙酰胺、硫代乙酰胺和氨基脲衍生物的酰化和烷基化反应，合成了几种新型含硫杂双环部分（4-11）。通过元素分析以及光谱数据（红外光谱、1H核磁共振和质谱）推断出产物的结构。所有新化合物都具有显著的抗菌活性，尤其是对尖孢镰刀菌。
