Miyasaka Y, Yoshimura M, Tabata S, Shozu A, Nishikawa M, Iwasaka T, Inada M
Second Department of Internal Medicine, Kansai Medical University, Osaka, Japan.
Thyroid. 1997 Aug;7(4):621-4. doi: 10.1089/thy.1997.7.621.
We report here a patient with recurrent Graves' disease on hemodialysis. She also suffered from angina pectoris, which was probably a manifestation of Graves' disease due to the increased oxygen demands in the presence of fixed coronary lesions. Although antithyroid drugs induced mild granulocytopenia, propylthiouracil (PTU) or methimazole (MMI) was not discontinued during the administration of granulocyte colony-stimulating factor (G-CSF). The patient received sodium iodine-131 therapy, and became euthyroid with no chest pain. To our knowledge, this is the first case that illustrated the usefulness of G-CSF for antithyroid drug-induced granulocytopenia prior to thyroid ablation for Graves' disease complicated with chronic renal failure and angina pectoris.
我们在此报告一名接受血液透析的复发性格雷夫斯病患者。她还患有心绞痛，这可能是格雷夫斯病的一种表现，因为在存在固定冠状动脉病变的情况下氧需求增加。尽管抗甲状腺药物引起了轻度粒细胞减少，但在给予粒细胞集落刺激因子（G-CSF）期间，丙硫氧嘧啶（PTU）或甲巯咪唑（MMI）并未停用。该患者接受了碘-131钠治疗，甲状腺功能恢复正常且无胸痛。据我们所知，这是第一例说明G-CSF在格雷夫斯病合并慢性肾衰竭和心绞痛的甲状腺消融术前对抗甲状腺药物所致粒细胞减少有用的病例。
