Altunbas H, Yazicioglu G, Balci M K, Karayalçin U, Undar L
Department of Endocrinology and Metabolism, Akdeniz University School of Medicine, Turkey.
Int J Clin Pract. 1999 Jul-Aug;53(5):396-7.
A 43-year-old female patient with Basedow-Graves' disease developed agranulocytosis in the eighth month of propylthiouracil therapy. After discontinuing the drug, a broad spectrum antibiotic regimen plus recombinant human granulocyte colony-stimulating factor (G-CSF), a human haematopoietic growth factor, were started. Her granulocyte count returned to normal with the second dose of G-CSF, and ulcerating pharyngitis improved rapidly. We think that in patients with propylthiouracil-induced agranulocytosis, G-CSF will reduce the risk and severity of infection, and should be accepted as a part of the standard therapy.
一名患有巴塞多-格雷夫斯病的43岁女性患者在丙硫氧嘧啶治疗的第八个月出现了粒细胞缺乏症。停药后，开始使用广谱抗生素方案加重组人粒细胞集落刺激因子（G-CSF），一种人类造血生长因子。第二次注射G-CSF后，她的粒细胞计数恢复正常，溃疡性咽炎迅速改善。我们认为，对于丙硫氧嘧啶引起的粒细胞缺乏症患者，G-CSF将降低感染风险和严重程度，应被视为标准治疗的一部分。
