阴茎镜检查、肿瘤细胞学和组织病理学在人乳头瘤病毒所致阴茎感染诊断中的重要性。
Importance of peniscopy, oncologic cytology and histopathology in the diagnosis of penile infection by human papillomavirus.
作者信息
Nicolau S M, Martins N V, Ferraz P E, Stávale J N, Gonçalves W J, Baracat E C, de Lima G R
机构信息
Department of Obstetrics and Gynecology, Escola Paulista de Medicina, São Paulo, Brazil.
出版信息
Sao Paulo Med J. 1997 Jan-Feb;115(1):1330-5. doi: 10.1590/s1516-31801997000100003.
INTRODUCTION
Male genital infection by human papillomavirus is of particular importance since it is often asymptomatic. The patient generally presents no clinical lesion. Therefore, men represent an important reservoir of virus, playing a special role in the transmission and perpetuation of the disease.
PATIENTS AND METHODS
In the present prospective clinical trial study, 190 sex partners of women with genital infection by human papillomavirus, associated or not with cervical intraepithelial neoplasia, were investigated. All patients were unaware of or denied the presence of a genital lesion.
RESULTS
Cytologic examination revealed koilocytosis in 9 cases (4.7%) in the urethra and in 3 cases (1.6%) in the corona of the glans and the distal prepuce. Peniscopy with the previous use of 5% acetic acid revealed white lesions in 97.9% of the patients. Toluidine blue stained most of the lesions. At least one fragment revealed koilocytosis in the histopathologic study of 97 cases (51.05%).
CONCLUSION
The three methods complement one another, allowing a more precise diagnosis of the infection in men.
引言
人乳头瘤病毒引起的男性生殖器感染尤为重要，因为它通常无症状。患者一般无临床病变。因此，男性是病毒的重要储存宿主，在疾病的传播和持续存在中发挥着特殊作用。
患者与方法
在本前瞻性临床试验研究中，对190名感染人乳头瘤病毒的女性的性伴侣进行了调查，这些女性伴有或不伴有宫颈上皮内瘤变。所有患者均未意识到或否认存在生殖器病变。
结果
细胞学检查显示，9例（4.7%）尿道出现挖空细胞，3例（1.6%）龟头冠状沟和包皮远端出现挖空细胞。预先使用5%醋酸进行阴茎镜检查发现，97.9%的患者有白色病变。甲苯胺蓝可使大多数病变染色。在97例（51.05%）患者的组织病理学研究中，至少有一个切片显示有挖空细胞。
结论
这三种方法相互补充，能更准确地诊断男性感染情况。
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