Prohászka Z, Thiel S, Ujhelyi E, Szlávik J, Bánhegyi D, Füst G
3rd Department of Medicine, Semmelweis Medical University, Budapest, Hungary.
Immunol Lett. 1997 Aug;58(3):171-5. doi: 10.1016/s0165-2478(97)00084-9.
Serum concentrations of mannan-binding lectin (MBL) were determined in the sera of 67 HIV-seropositive patients in different stages of HIV disease and in the sera of 75 HIV-seronegative healthy individuals. In the asymptomatic (AS) HIV-infected persons MBL concentrations were found to be significantly (P < 0.05) lower than in the HIV-seronegative controls, whereas in the AIDS patients they were not. Very low (< or = 25 ng/ml) MBL serum concentrations were detected in 5/19 (26.3%) and 7/75 (9.3%) of the AS HIV-seropositive and HIV-seronegative individuals, respectively (P = 0.06). In the sera of the HIV-infected patients, MBL levels positively correlated to the neopterin concentrations (Spearman correlation coefficient, 0.401, P = 0.0009) while they negatively correlated to the percentage (-0.447, P = 0.0011) and absolute number (-0.453, P = 0.0012) of the CD4+ lymphocytes. These observations indicate that MBL level, which is under strict genetic control, may influence the susceptibility to HIV infection and the progression of HIV disease.
测定了67例处于不同HIV疾病阶段的HIV血清阳性患者以及75例HIV血清阴性健康个体血清中的甘露聚糖结合凝集素（MBL）浓度。在无症状（AS）HIV感染者中，发现MBL浓度显著（P < 0.05）低于HIV血清阴性对照组，而在艾滋病患者中则不然。在AS HIV血清阳性个体和HIV血清阴性个体中，分别有5/19（26.3%）和7/75（9.3%）检测到极低（≤25 ng/ml）的MBL血清浓度（P = 0.06）。在HIV感染患者的血清中，MBL水平与新蝶呤浓度呈正相关（斯皮尔曼相关系数，0.401，P = 0.0009），而与CD4 +淋巴细胞的百分比（-0.447，P = 0.0011）和绝对数量（-0.453，P = 0.0012）呈负相关。这些观察结果表明，受严格基因控制的MBL水平可能会影响对HIV感染的易感性以及HIV疾病的进展。
