Tajima Y, Utsumi N, Suzuki S, Fujita K, Takahashi H
Department of Oral Pathology, Meikai University School of Dentistry, Saitama, Japan.
Pathol Int. 1997 Aug;47(8):564-8. doi: 10.1111/j.1440-1827.1997.tb04541.x.
An ameloblastic fibrosarcoma (AFS) arising in the maxilla of a 14-year-old male is described. The tumor originated from the alveolar bone of the right maxilla with no apparent history of pre-existing lesion. Histologically, the lesion was composed of benign-appearing epithelial islands and strands scattered within an exceedingly cellular mass of mesenchymal tissue comprising a large number of stellate-and spindle-shaped fibroblast-like cells with marked pleomorphism. Occasional cementum-like calcification was also noted. Immunohistochemically, the neoplastic mesenchymal cells were positive only for vimentin, whereas the ameloblast-like epithelial component showed a distinctly positive reaction for wide-spectrum keratin and squamous cytokeratin. Clinicopathological features of the current case, as well as previously reported examples of AFS originating from the maxilla, are briefly discussed.
本文描述了一例发生于一名14岁男性上颌骨的成釉细胞纤维肉瘤（AFS）。肿瘤起源于右上颌骨的牙槽骨，无明显的既往病变史。组织学上，病变由外观良性的上皮岛和条索组成，散在于细胞极为丰富的间叶组织中，间叶组织包含大量具有明显多形性的星状和梭形成纤维细胞样细胞。还可见偶尔的类牙骨质钙化。免疫组化显示，肿瘤性间叶细胞仅波形蛋白阳性，而成釉细胞样上皮成分对广谱角蛋白和鳞状细胞角蛋白呈明显阳性反应。本文简要讨论了该病例的临床病理特征以及先前报道的起源于上颌骨的AFS病例。
