Leung A, Shapiro B, Hattner R, Kim E, de Kraker J, Ghazzar N, Hartmann O, Hoefnagel C A, Jamadar D A, Kloos R, Lizotte P, Lumbroso J, Rufini V, Shulkin B L, Sisson J C, Thein A, Troncone L
Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor 48109-0028, USA.
J Nucl Med. 1997 Sep;38(9):1352-7.
The high sensitivity of metaiodobenzylguanidine (MIBG) scintigraphy for sympathomedullary tumors such as neuroblastoma and pheochromocytoma is well documented. The specificity of MIBG scintigraphy for these tumors is also high but has been incompletely characterized for other neural crest tumors and non-neural crest tumors of childhood.
The medical records and MIBG scans of all children who had undergone MIBG scintigraphy for known or suspected neuroblastoma or pheochromocytoma were retrospectively reviewed at five major referral centers. Those patients found to have pathologies other than neuroblastoma or pheochromocytoma form the basis of this study.
One hundred children with a total of 110 lesions met the inclusion criteria. All had negative MIBG scans except 1 of 2 children with infantile myofibromatosis, 1 of 2 with neuroendocrine carcinomas, 1 of 2 with pancreaticoblastomas and 1 of 10 with primitive neuroectodermal tumors.
MIBG scintigraphy is highly specific for neuroblastoma and pheochromocytoma. Only 4% (4/100) of nonsympathomedullary tumors (non-pheochromocytoma and non-neuroblastoma) in childhood showed MIBG uptake, of which only 2% (2/100) were of non-neural crest origin.
间碘苄胍（MIBG）闪烁扫描术对神经母细胞瘤和嗜铬细胞瘤等交感神经髓质肿瘤具有高敏感性，这一点已有充分文献记载。MIBG闪烁扫描术对这些肿瘤的特异性也很高，但对于其他儿童期神经嵴肿瘤和非神经嵴肿瘤，其特异性尚未完全明确。
在五个主要转诊中心对所有因已知或疑似神经母细胞瘤或嗜铬细胞瘤而接受MIBG闪烁扫描术的儿童的病历和MIBG扫描结果进行回顾性研究。本研究以那些被发现患有除神经母细胞瘤或嗜铬细胞瘤之外其他病理疾病的患者为基础。
100名儿童共有110处病灶符合纳入标准。除2例婴儿肌纤维瘤病患儿中的1例、2例神经内分泌癌患儿中的1例、2例胰腺母细胞瘤患儿中的1例以及10例原始神经外胚层肿瘤患儿中的1例之外，所有患儿的MIBG扫描结果均为阴性。
MIBG闪烁扫描术对神经母细胞瘤和嗜铬细胞瘤具有高度特异性。儿童期非交感神经髓质肿瘤（非嗜铬细胞瘤和非神经母细胞瘤）中只有4%（4/100）显示有MIBG摄取，其中只有2%（2/100）起源于非神经嵴。
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