在粟酒裂殖酵母nmt1（thi3）启动子中鉴定参与硫胺素调节基因表达的DNA元件。
Identification of a DNA element in the fission yeast Schizosaccharomyces pombe nmt1 (thi3) promoter involved in thiamine-regulated gene expression.
作者信息
Zurlinden A, Schweingruber M E
机构信息
Institute of General Microbiology, University of Bern, Switzerland.
出版信息
J Bacteriol. 1997 Sep;179(18):5956-8. doi: 10.1128/jb.179.18.5956-5958.1997.
Abstract
To define DNA elements involved in thiamine-regulated transcription of the Schizosaccharomyces pombe gene nmt1 (thi3), we analyzed several nmt1 promoter constructs. We detected a DNA element which is required for promoter activation in the absence of thiamine. It is located 54 to 62 bp upstream of the TATA box and matches the consensus sequence of the binding site for the mammalian transcription factor C/EBP (CAAT/enhancer binding protein). We show that the element specifically binds proteins.
摘要
为了确定参与粟酒裂殖酵母基因nmt1（thi3）硫胺素调节转录的DNA元件，我们分析了几种nmt1启动子构建体。我们检测到一个在无硫胺素时启动子激活所必需的DNA元件。它位于TATA框上游54至62 bp处，与哺乳动物转录因子C/EBP（CAAT/增强子结合蛋白）结合位点的共有序列相匹配。我们表明该元件能特异性结合蛋白质。
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