Brennan T D, Miller A S, Chen S Y
Hospital of the University of Pennsylvania, Philadelphia, USA.
J Oral Maxillofac Surg. 1997 Sep;55(9):932-5. doi: 10.1016/s0278-2391(97)90062-8.
This study evaluated the demographics, treatment outcomes, histology, and basement lamina characteristics of a large series of lymphangiomas.
Forty-seven lymphangiomas of the oral cavity were evaluated microscopically and representative specimens were also evaluated immunohistochemically (IMH) and by electron microscopy (EM).
Patient's ages ranged from 2 to 84 years. The dorsal surface of the tongue was the most common site. Discontinuities in the basement membrane were detected with IMH and EM.
The discontinuous basement membrane may explain why sclerosing agents have not been effective as a form of treatment for lymphangioma.
本研究评估了大量淋巴管瘤的人口统计学特征、治疗结果、组织学及基底膜特征。
对47例口腔淋巴管瘤进行显微镜检查，并对代表性标本进行免疫组织化学（IMH）和电子显微镜（EM）评估。
患者年龄范围为2至84岁。舌背是最常见的部位。通过IMH和EM检测到基底膜的连续性中断。
基底膜的连续性中断可能解释了硬化剂作为淋巴管瘤治疗形式为何无效。
