B cell-deficient muMT mice as an experimental model for Mycoplasma infections in X-linked agammaglobulinemia.
作者信息
Berglöf A, Sandstedt K, Feinstein R, Bölske G, Smith C I
机构信息
Department of Immunology, Microbiology, Pathology, and Infectious Diseases, Karolinska Institute, Huddinge Hospital, Sweden.
出版信息
Eur J Immunol. 1997 Aug;27(8):2118-21. doi: 10.1002/eji.1830270841.
PMID:9295053
Abstract
B cell-deficient muMT mice were investigated as an experimental model for human X-linked agammaglobulinemia (XLA). Mice were intranasally infected with Mycoplasma pulmonis and in 16 out of 17 muMT mice, dissemination of the bacteria from the airways was observed. More than 50% of these mice developed arthritis and/or changes in periarticular tissues. Mycoplasmal infection in muMT mice thus resembles the disease seen in XLA patients implying the usefulness of the model.
摘要
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