Tanaka T, Seki A, Fujii J, Kurihara H, Ikeda M
Tohoku J Exp Med. 1977 Oct;123(2):177-83. doi: 10.1620/tjem.123.177.
The content and turnover of norepinephrine (NE) in the hypothalamus, midbrain, pons-medulla, mesenteric artery, aorta and left ventricle were studied in the normal rabbit. Turnover rate of NE was determined by measuring the rate of decline in NE content of the tissue after blockade of synthesis with alpha-methyl-p-tyrosine. The NE content of the hypothalamus (1.44+/-0.03 microgram/g) was significantly higher than those of the midbrain (0.25+/-0.01 microgram/g) and the pons-medulla (0.36+/-0.01 microgram/g) (p less than 0.001), whereas the rate constant of NE turnover for the pons-medulla (0.213+/-0.009 hr-1) was significantly greater than those for the hypothalamus (0.164+/-0.008 hr-1, p less than 0.001) and the midbrain (0.180+/-0.008 hr-1, p less than 0.01). In the cardiovascular tissues examined, the NE content was highest in the mesenteric artery (6.33+/-0.19 microgram/g), moderate in the left ventricle (2.08+/-0.10 microgram/g) and lowest in the aorta (0.70+/-0.06 microgram/g). The differences among them were significant (p less than 0.001). However, the rate constant of NE turnover for the aorta (0.119+/-0.014 hr-1) was significantly greater than those for the mesenteric artery (0.059+/-0.008 hr-1, p less than 0.001) and the left ventricle (0.069+/-0.006 hr-1, p less than 0.005). The turnover rate of NE in the mesenteric artery was high, 0.372 microgram/g-hr, which suggests the very active NE synthesis. These results indicate that there are regional differences in content and turnover of NE of the cardiovascular tissues as well as of the brain.
研究了正常家兔下丘脑、中脑、脑桥-延髓、肠系膜动脉、主动脉和左心室中去甲肾上腺素（NE）的含量及更新情况。通过用α-甲基-p-酪氨酸阻断NE合成后，测量组织中NE含量的下降速率来确定NE的更新率。下丘脑的NE含量（1.44±0.03微克/克）显著高于中脑（0.25±0.01微克/克）和脑桥-延髓（0.36±0.01微克/克）（p＜0.001），而脑桥-延髓的NE更新速率常数（0.213±0.009小时-1）显著高于下丘脑（0.164±0.008小时-1，p＜0.001）和中脑（0.180±0.008小时-1，p＜0.01）。在所检查的心血管组织中，NE含量在肠系膜动脉中最高（6.33±0.19微克/克），在左心室中中等（2.08±0.10微克/克），在主动脉中最低（0.70±0.06微克/克）。它们之间的差异具有显著性（p＜0.001）。然而，主动脉的NE更新速率常数（0.119±0.014小时-1）显著高于肠系膜动脉（0.059±0.008小时-1，p＜0.001）和左心室（0.069±0.006小时-1，p＜0.005）。肠系膜动脉中NE的更新率较高，为0.372微克/克·小时，这表明NE合成非常活跃。这些结果表明，心血管组织以及大脑中NE的含量和更新存在区域差异。
