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Toxicity of organotin compounds. III. Suppression of thymus-dependent immunity in rats by di-n-butyltindichloride and di-n-octyltindichloride.

作者信息

Seinen W, Vos J G, van Krieken R, Penninks A, Brands R, Hooykaas H

出版信息

Toxicol Appl Pharmacol. 1977 Oct;42(1):213-24. doi: 10.1016/0041-008x(77)90211-3.

DOI:10.1016/0041-008x(77)90211-3
PMID:929604
Abstract
摘要

相似文献

1
Toxicity of organotin compounds. III. Suppression of thymus-dependent immunity in rats by di-n-butyltindichloride and di-n-octyltindichloride.有机锡化合物的毒性。III. 二正丁基二氯化锡和二正辛基二氯化锡对大鼠胸腺依赖性免疫的抑制作用
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Lymphocytotoxicity and immunosuppression by organotin compounds. Suppression of graft-versus-host reactivity, blast transformation, and E-rosette formation by di-n-butyltindichloride and di-n-octyltindichloride.有机锡化合物的淋巴细胞毒性和免疫抑制作用。二正丁基二氯化锡和二正辛基二氯化锡对移植物抗宿主反应、母细胞转化和E花环形成的抑制作用。
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[Effects of dialkyl tin salts on the immune system].二烷基锡盐对免疫系统的影响
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Toxicity of organotin compounds. I. Atrophy of thymus and thymus-dependent lymphoid tissue in rats fed di-n-octyltindichloride.有机锡化合物的毒性。I. 喂食二正辛基二氯化锡的大鼠胸腺及胸腺依赖淋巴组织萎缩
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Effect of triphenyltin hydroxide on the immune system of the rat.氢氧化三苯基锡对大鼠免疫系统的影响。
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Toxicity of organotin compounds. II. Comparative in vivo and in vitro studies with various organotin and organolead compounds in different animal species with special emphasis on lymphocyte cytotoxicity.
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Toxic effects of di-n-octyltin dichloride on the thymus in mice.二正辛基二氯化锡对小鼠胸腺的毒性作用。
Arch Toxicol Suppl. 1979(2):315-20. doi: 10.1007/978-3-642-67265-1_29.

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Dibutyltin disrupts glucocorticoid receptor function and impairs glucocorticoid-induced suppression of cytokine production.二丁基锡会破坏糖皮质激素受体功能，并损害糖皮质激素诱导的细胞因子产生抑制作用。
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Organotins disrupt the 11beta-hydroxysteroid dehydrogenase type 2-dependent local inactivation of glucocorticoids.有机锡会破坏11β-羟基类固醇脱氢酶2型依赖性糖皮质激素的局部失活。
Environ Health Perspect. 2005 Nov;113(11):1600-6. doi: 10.1289/ehp.8209.
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Selective inhibition of immature CD4-CD8+ thymocyte proliferation, but not differentiation, by the thymus atrophy-inducing compound di-n-butyltin dichloride.胸腺萎缩诱导化合物二正丁基二氯化锡对未成熟CD4-CD8+胸腺细胞增殖具有选择性抑制作用，但对其分化无影响。
Immunology. 1994 Feb;81(2):261-7.
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Immunology. 1993 Apr;78(4):616-22.
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Immunotoxicology: suppressive and stimulatory effects of drugs and environmental chemicals on the immune system. A discussion.免疫毒理学：药物和环境化学物质对免疫系统的抑制和刺激作用。讨论
Arch Toxicol. 1989;63(4):257-73. doi: 10.1007/BF00278639.
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Increase of DT-diaphorase activity and atrophy of thymus by organotin compounds.
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Comparative teratogenicity of di-n-butyltin diacetate with n-butyltin trichloride in rats.大鼠中二醋酸二正丁基锡与三氯化正丁基锡的比较致畸性
Arch Environ Contam Toxicol. 1992 Aug;23(2):216-22. doi: 10.1007/BF00212278.
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The organotin-induced thymus atrophy, characterized by depletion of CD4+ CD8+ thymocytes, is preceded by a reduction of the immature CD4- CD8+ TcR alpha beta-/low CD2high thymoblast subset.有机锡诱导的胸腺萎缩，其特征为CD4+CD8+胸腺细胞耗竭，在此之前未成熟的CD4-CD8+TcRαβ-/低CD2高胸腺母细胞亚群会减少。
Immunology. 1992 Jun;76(2):203-8.