[铜绿假单胞菌血清分型对β-内酰胺类和氨基糖苷类敏感性的三中心研究]

[Tricentric study of the sensitivity of Pseudomonas aeruginosa serotyping to beta-lactams and aminoglycosides].

作者信息

Vachée A, Scheftel J M, Husson M O, Izard D, Ross P, Monteil H

机构信息

Laboratoire de Bactériologie-Hygiène, CHRU Lille, France.

出版信息

Pathol Biol (Paris). 1997 May;45(5):357-62.

PMID:9296084

Abstract

The aim of this study was to evaluate the susceptibility of 300 Pseudomonas aeruginosa strains to 6 beta-lactams and to 2 aminoglycosides and to compare this susceptibility according to the serotype, the sample nature, the unit activity and the geographic situation of the hospital. The susceptibility level was ascertained using the disk method. Serotyping of the strains was also performed. Susceptibility level was 67% for ticarcillin, 82% for piperacillin-tazobactam combination, 85% for ceftazidim, 81% for cefepim, 74% for aztreonam, 83% for imipenem, 73% for tobramycin and 86% for amikacin. Non-serotypable strains represented 20.6%. The most common serotypes were O6 (19%) and O11 (13%). Discrepancies between cefepime and ceftazidime were found in 15 strains after MIC determination, 6 of them were O12 strains. It appears that strain susceptibility was function of the serotype distribution. Cefepime exhibited outstanding activity against P. aeruginosa, similar to ceftazidim activity.

摘要

本研究的目的是评估300株铜绿假单胞菌对6种β-内酰胺类药物和2种氨基糖苷类药物的敏感性，并根据血清型、样本性质、单位活性和医院的地理位置比较这种敏感性。使用纸片法确定敏感性水平。还对菌株进行了血清分型。替卡西林的敏感性水平为67%，哌拉西林-他唑巴坦组合为82%，头孢他啶为85%，头孢吡肟为81%，氨曲南为74%，亚胺培南为83%，妥布霉素为73%，阿米卡星为86%。不可分型菌株占20.6%。最常见的血清型是O6（19%）和O11（13%）。在测定MIC后，发现15株菌株中头孢吡肟和头孢他啶之间存在差异，其中6株是O12菌株。看来菌株敏感性是血清型分布的函数。头孢吡肟对铜绿假单胞菌表现出出色的活性，与头孢他啶的活性相似。