Bert F, Briaud I, Branger C, Lambert-Zechovsky N
Service de Microbiologie, Hôpital Beaujon, Clichy, France.
Pathol Biol (Paris). 1996 May;44(5):329-32.
The in vitro activity of ticarcillin, ticarcillin-clavulanic acid, piperacillin, piperacillin-tazobactam, cefsulodin, ceftazidime, cefepime, cefpirome and aztreonam was evaluated against 130 isolates of Pseudomonas aeruginosa with various beta-lactam phenotypes. MICs were determined by the agar dilution method and inhibition method and inhibition zones by the disk test. The resistance mechanisms were characterized by the iodometric method. The activity of cefepime was greater than that of cefpirome whatever the resistance phenotype. Some ticarcillin-susceptible strains were intermediate to cefepime and cefpirome. Most strains with a penicillinase or "intrinsic resistance" phenotype were susceptible to ceftazidime but intermediate to cefepime and cefpirome. Only 10% of cephalosporinase-over-producing strains remained susceptible to cefepime.
对130株具有不同β-内酰胺表型的铜绿假单胞菌分离株，评估了替卡西林、替卡西林-克拉维酸、哌拉西林、哌拉西林-他唑巴坦、头孢磺啶、头孢他啶、头孢吡肟、头孢匹罗和氨曲南的体外活性。采用琼脂稀释法测定最低抑菌浓度（MIC），采用纸片扩散法测定抑菌圈。通过碘量法确定耐药机制。无论耐药表型如何，头孢吡肟的活性均高于头孢匹罗。一些对替卡西林敏感的菌株对头孢吡肟和头孢匹罗呈中介敏感。大多数具有青霉素酶或“固有耐药性”表型的菌株对头孢他啶敏感，但对头孢吡肟和头孢匹罗呈中介敏感。只有10%的高产头孢菌素酶菌株对头孢吡肟仍敏感。
