Vajo Z, McDonald M, Takahashi B, Zafar H, Srivathsan K, Dachman W D
Department of Medicine, Maricopa Medical Center, Phoenix, Arizona 85008, USA.
Br J Clin Pharmacol. 1997 Sep;44(3):285-8. doi: 10.1046/j.1365-2125.1997.00658.x.
The aim of this study was to determine whether young, normotensive blacks who have been recently demonstrated to have a venodilator response to isoprenaline decreased compared with whites, also have an decreased vasodilatory response to bradykinin.
Eleven black and 11 white subjects were studied. Full dose-response curves to bradykinin (dosing range 0.5-500 ng min-1) were generated in hand veins preconstricted with phenylephrine (dosing range 20-6800 ng min-1).
The groups had a similar maximal response to bradykinin (57.6 +/- 32.2% vs 67.8 +/- 49.3%, P = NS 95% confidence interval for the difference (CI): -47.3, 26.8). Also, the log of the dose that produced half maximal response to bradykinin was similar for the two groups (0.89 +/- 0.58 vs 0.78 +/- 0.61 ng min-1, P = NS, 95% CI: -0.42, 0.64). There was no difference between the two groups in the log dose of phenylephrine necessary to produce 80% constriction of the hand vein.
Diminished vasodilatory response to endothelium-derived relaxing factor (EDRF) does not seem to be associated with the increased prevalence of hypertension in blacks.
本研究旨在确定近期已证明对异丙肾上腺素的静脉舒张反应较白人降低的年轻血压正常黑人，对缓激肽的血管舒张反应是否也降低。
对11名黑人受试者和11名白人受试者进行了研究。在用去氧肾上腺素（剂量范围20 - 6800 ng/min）预收缩的手部静脉中，生成了对缓激肽（剂量范围0.5 - 500 ng/min）的完整剂量反应曲线。
两组对缓激肽的最大反应相似（57.6±32.2%对67.8±49.3%，P =无显著性差异，差异的95%置信区间(CI)：-47.3, 26.8）。此外，两组产生对缓激肽半数最大反应的剂量对数相似（0.89±0.58对0.78±0.61 ng/min，P =无显著性差异，95% CI：-0.42, 0.64）。两组在使手部静脉产生80%收缩所需的去氧肾上腺素剂量对数方面没有差异。
对内皮源性舒张因子（EDRF）的血管舒张反应减弱似乎与黑人高血压患病率增加无关。
