Rabelo Eneida R, Rohde Luis E, Schaan Beatriz D, Rubira Marcelo C, Ruschel Karen B, Plentz Rodrigo D M, Consolim-Colombo Fernanda M, Irigoyen Maria Cláudia, Moreno Junior Heitor
Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil.
Clinics (Sao Paulo). 2008 Oct;63(5):677-82. doi: 10.1590/s1807-59322008000500017.
The evaluation of endothelial function has been performed in the arterial bed, but recently evaluation within the venous system has also been explored. Endothelial function studies employ different drugs that act as endothelium-dependent vasodilatory response inductors.
The aim of this study is to compare the endothelium-dependent venous vasodilator response mediated by either acetylcholine or bradykinin in healthy volunteers.
Changes in vein diameter after phenylephrine-induced venoconstriction were measured to compare venodilation induced by acetylcholine or bradykinin (linear variable differential transformer dorsal hand vein technique). We studied 23 healthy volunteers; 31% were male, and the subject had a mean age of 33 +/- 8 years and a mean body mass index of 23 +/- 2 kg/m(2). The maximum endothelium-dependent venodilation was similar for both drugs (p = 0.13), as well as the mean responses for each dose of both drugs (r = 0.96). The maximum responses to acetylcholine and bradykinin also had good agreement.
There were no differences between acetylcholine and bradykinin as venodilators in this endothelial venous function investigation.
内皮功能的评估已在动脉床中进行，但最近也有人探索在静脉系统内进行评估。内皮功能研究使用不同的药物作为内皮依赖性血管舒张反应诱导剂。
本研究旨在比较健康志愿者中由乙酰胆碱或缓激肽介导的内皮依赖性静脉血管舒张反应。
测量去氧肾上腺素诱导静脉收缩后静脉直径的变化，以比较乙酰胆碱或缓激肽诱导的静脉舒张（线性可变差动变压器手背静脉技术）。我们研究了23名健康志愿者；31%为男性，受试者的平均年龄为33±8岁，平均体重指数为23±2kg/m²。两种药物的最大内皮依赖性静脉舒张相似（p=0.13），两种药物各剂量的平均反应也相似（r=0.96）。对乙酰胆碱和缓激肽的最大反应也具有良好的一致性。
在这项内皮静脉功能研究中，乙酰胆碱和缓激肽作为静脉舒张剂没有差异。
