Xue F S, Tong S Y, Liao X, Liu J H, An G, Luo L K
Department of Anesthesiology, Plastic Surgery Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People's Republic of China.
Anesth Analg. 1997 Sep;85(3):667-71. doi: 10.1097/00000539-199709000-00033.
To determine differences from dose-response and time-course of rocuronium between male and female patients, 60 adult patients (30 male and 30 female), ASA grade I, aged 17-52 yr, undergoing elective plastic surgery were studied. Anesthesia was maintained with 60% nitrous oxide in oxygen, thiopental, and incremental doses of fentanyl as required. Neuromuscular function was assessed mechanomyographically with train-of-four (TOF) stimulation at the wrist every 12 s, and the percentage depression of the T1 response was used as the study variable. The dose-response relationship of rocuronium was determined by a cumulative dose-response technique. The results showed that the dose-response curve of rocuronium in the men was shifted to the right, indicating a decrease in the sensitivity to rocuronium-induced neuromuscular block versus the women. The 50%, 90%, and 95% effective doses of rocuronium were 178.4 +/- 53.7, 358.7 +/- 101.3, and 386.2 +/- 113.4 microg/kg, respectively, in male patients, and 128.8 +/- 42.5, 252.8 +/- 51.7, and 274.4 +/- 59.4 microg/kg in female patients. After an intravenous administration of total dose of 400 microg/kg rocuronium, neuromuscular block was significantly longer in the men than in the women. The duration of peak effect, clinical duration, and total duration were 6.5 +/- 3.0, 12.5 +/- 4.9, and 33.6 +/- 8.7 min, respectively, in male patients, and 11.8 +/- 2.7, 18.5 +/- 5.3, and 46.8 +/- 9.6 min in female patients. We conclude that women were approximately 30% more sensitive to rocuronium compared with men.
The authors found that women were 30% more sensitive to rocuronium than men. This suggests that the routine dose of rocuronium should be reduced in women compared with men.
为确定男性和女性患者罗库溴铵剂量反应及时间过程的差异，对60例成年患者（30例男性和30例女性）进行了研究，这些患者ASA分级为I级，年龄17 - 52岁，接受择期整形手术。麻醉维持采用60%氧化亚氮与氧气混合、硫喷妥钠，并根据需要递增剂量的芬太尼。每12秒在腕部通过四个成串刺激（TOF）以肌机械图法评估神经肌肉功能，T1反应的抑制百分比用作研究变量。罗库溴铵的剂量反应关系通过累积剂量反应技术确定。结果显示，男性患者罗库溴铵的剂量反应曲线右移，表明与女性相比，对罗库溴铵诱导的神经肌肉阻滞的敏感性降低。男性患者罗库溴铵的50%、90%和95%有效剂量分别为178.4±53.7、358.7±101.3和386.2±113.4μg/kg，女性患者分别为128.8±42.5、252.8±51.7和274.4±59.4μg/kg。静脉注射罗库溴铵总剂量400μg/kg后，男性患者神经肌肉阻滞时间明显长于女性患者。男性患者的效应峰值持续时间、临床持续时间和总持续时间分别为6.5±3.0、12.5±4.9和33.6±8.7分钟，女性患者分别为11.8±2.7、18.5±5.3和46.8±9.6分钟。我们得出结论，与男性相比，女性对罗库溴铵的敏感性约高30%。
作者发现女性对罗库溴铵的敏感性比男性高30%。这表明与男性相比，女性罗库溴铵的常规剂量应降低。
