衰老对纹状体中含D1和D2多巴胺受体神经元对 kainic 酸易损性的影响。

Effect of aging on vulnerability of striatal D1 and D2 dopamine receptor-containing neurons to kainic acid.

作者信息

Zhang L, Joseph J A, Roth G S

机构信息

Laboratory of Cellular and Molecular Biology, Gerontology Research Center, National Institute on Aging, National Institutes of Health, Johns Hopkins Bayview Medical Center, Baltimore, MD 21224, USA.

出版信息

Brain Res. 1997 Jul 25;763(2):264-6. doi: 10.1016/s0006-8993(97)00485-x.

DOI:10.1016/s0006-8993(97)00485-x

PMID:9296569

Abstract

Kainic acid lesions elicit reductions in ligand binding to both D1 and D2 striata dopamine receptors in young and old rats. Relative reductions are greatest for both receptors in young animals than old. In addition, D1 receptor binding is reduced more than D2 at both ages. These findings support the idea that those dopamine receptor neurons lost during aging may reside in a kainic acid sensitive population.

摘要

海人酸损伤会导致幼鼠和成年鼠纹状体中D1和D2多巴胺受体的配体结合减少。幼鼠中两种受体的相对减少幅度比成年鼠更大。此外，在两个年龄段中，D1受体结合的减少幅度都大于D2受体。这些发现支持了这样一种观点，即衰老过程中丢失的那些多巴胺受体神经元可能存在于对海人酸敏感的群体中。