Michalak S, Skrzydlewski Z, Woroniecki A, Lewandowska M, Zdanowicz A
Samodzielnej Pracowni Analityki Klinicznej AM w Białymstoku.
Ginekol Pol. 1997 Jan;68(1):17-21.
Cathepsin D activity during labour and puerperium in normal cases and those complicated by mild or moderate EPH-Gestosis was examined. Sera from maternal and umbilical cord blood, as well as the extraplacental blood and amniotic fluid were used for determinations. The gestational age of physiologic pregnancies and pregnancies complicated by EPH-Gestosis was 40 weeks. The first stage of labour was from 4 to 6 hours. The second stage of labour was over 10 minutes. In the group of women with mild and moderate EPH-Gestosis, the maternal serum activities on the third and fifth day of puerperium were significantly lower than in nonaffected subjects. In patients with moderate EPH-Gestosis, the activities in the maternal sera on the first day of puerperium, and in the umbilical blood were decreased when compared to controls. Uniformly, activities of the studied enzyme have been found to be lower in the umbilical cord blood sera than in the sera of the parturients. In cases of mild and moderate EPH-Gestosis the enzyme activity in the amniotic fluid was much lower than in controls, whereas in the extraplacental blood it was much higher.
研究了正常分娩及产褥期以及合并轻度或中度妊娠高血压综合征（EPH - 妊娠中毒症）患者分娩及产褥期组织蛋白酶D的活性。使用母体和脐带血血清以及胎盘外血液和羊水进行测定。生理性妊娠和合并EPH - 妊娠中毒症妊娠的孕周均为40周。第一产程为4至6小时。第二产程超过10分钟。在轻度和中度EPH - 妊娠中毒症女性组中，产褥期第三天和第五天母体血清活性显著低于未受影响的受试者。与对照组相比，中度EPH - 妊娠中毒症患者产褥期第一天母体血清及脐带血中的活性降低。一致地，已发现所研究酶在脐带血血清中的活性低于产妇血清中的活性。在轻度和中度EPH - 妊娠中毒症病例中，羊水中的酶活性远低于对照组，而胎盘外血液中的酶活性则远高于对照组。
