Kostrzhevs'ka O G, Kolesnikova I M, Korotkoruchko V P, Grigor'eva T L
Ukr Biokhim Zh. 1977 Nov-Dec;49(6):19-23.
Heterogeneity of proteins of blood serum high-molecular fraction in healthy people, patients with cancer and those with pathologies of nonmalignant nature was studied by the method of disc electrophoresis in 4% polyacrylamide gel. It is established that under conditions of the experiment sharp differences are observed in heterogeneity of studied proteins manifesting in a growth of the discrete electrophoretic bands in disc electrophoregrams of high-molecular fractions of sera from the cancer patients. Disc electrophoregrams of proteins of the studied fractions from the sera of patients with nonmalignant pathologies also differ from those of control groups, though not so sharply as when comparing the preparations obtained from the sera of healthy people and cancer patients. Possible reasons of the observed differences are discussed.
采用在4%聚丙烯酰胺凝胶中进行圆盘电泳的方法，研究了健康人、癌症患者以及非恶性疾病患者血清高分子组分蛋白质的异质性。结果表明，在实验条件下，所研究蛋白质的异质性存在显著差异，表现为癌症患者血清高分子组分圆盘电泳图谱中离散电泳条带的增加。非恶性疾病患者血清中所研究组分蛋白质的圆盘电泳图谱也与对照组不同，不过与健康人和癌症患者血清制备物相比，差异没有那么明显。文中讨论了观察到这些差异的可能原因。
