Tsau Y K, Lee P I, Chang L Y, Chen C H
Department of Pediatrics, National Taiwan University Hospital, Taipei, R.O.C.
Zhonghua Min Guo Xiao Er Ke Yi Xue Hui Za Zhi. 1997 Jul-Aug;38(4):276-81.
Using quantitative echogenicity, the correlation between renal cortical echogenicity and renal function (serum creatinine) was evaluated in pediatric renal diseases. The kidney/liver echogenicity ratio (K/ L ratio) was measured by computerized amplitude histogram in 20 healthy children as well as in 45 children with renal diseases, including 12 glomerulonephritis with chronic renal failure (CRF), 9 anatomic-related CRF, 9 glomerulonephritis with acute renal failure (ARF), 5 nephrotoxic ARF, and 10 glomerulonephritis without renal failure. All children were above six years of age. Simultaneous serum creatinine was available during the procedure in all patients. The overall K/L ratio was 1.38 +/- 0.26 for CRF and 1.14 +/- 0.18 for ARF (p = 0.007), while the overall serum creatinine was 312 +/- 160 mumol/L (3.5 +/- 1.8 mg/dl) and 191 +/- 73 mumol/L (2.2 +/- 0.8 mg/dl), respectively (p = 0.013). K/L ratio was higher in CRF at a higher, or even at a comparable serum creatinine level, than in ARF. For patients with glomerulonephritis, K/L ratio was highest in those with CRF, next in those with ARF. Even in glomerulonephritis without renal failure, the K/L ratio was higher than in normal controls. There was a positive correlation between K/L ratio and serum creatinine concentration in glomerulonephritis with or without renal failure (r = 0.69, p < 0.001). These results suggest that the degree of increased renal echogenicity may reflect the severity of the renal disease. The K/L ratio measured by quantitative echogenicity may provide an additional simple noninvasive method to monitor the progression of glomerulonephritis.
利用定量回声强度，对小儿肾脏疾病中肾皮质回声强度与肾功能（血清肌酐）之间的相关性进行了评估。采用计算机化幅度直方图测量了20名健康儿童以及45名患有肾脏疾病儿童的肾/肝回声强度比（K/L比），其中包括12例伴有慢性肾衰竭（CRF）的肾小球肾炎、9例解剖学相关的CRF、9例伴有急性肾衰竭（ARF）的肾小球肾炎、5例肾毒性ARF以及10例无肾衰竭的肾小球肾炎。所有儿童均超过6岁。所有患者在检查过程中均同时获得了血清肌酐数据。CRF患者的总体K/L比为1.38±0.26，ARF患者为1.14±0.18（p = 0.007），而总体血清肌酐分别为312±160μmol/L（3.5±1.8mg/dl）和191±73μmol/L（2.2±0.8mg/dl）（p = 0.013）。在血清肌酐水平较高甚至相当的情况下，CRF患者的K/L比高于ARF患者。对于患有肾小球肾炎的患者，K/L比在CRF患者中最高，其次是ARF患者。即使在无肾衰竭的肾小球肾炎患者中，K/L比也高于正常对照组。在伴有或不伴有肾衰竭的肾小球肾炎中，K/L比与血清肌酐浓度呈正相关（r = 0.69，p < 0.001）。这些结果表明，肾回声增强的程度可能反映肾脏疾病的严重程度。通过定量回声强度测量的K/L比可能为监测肾小球肾炎的进展提供一种额外的简单无创方法。
