Lein M, Brux B, Jung K, Henke W, Koenig F, Stephan C, Schnorr D, Loening S A
Klinik für Urologie, Universitätsklinikum Charité, Humboldt Universität zu Berlin, Germany.
Eur J Clin Chem Clin Biochem. 1997 Aug;35(8):591-5. doi: 10.1515/cclm.1997.35.8.591.
Elimination kinetics of serum total and free prostate-specific antigen were studied for a ten days course after radical retropubic prostatectomy on 11 patients suffering from organ confined prostate cancer. Samples were taken before operation, immediately after finishing the operation and 1, 2, 3, 4, 5, 6 h after prostatectomy and then once a day for the following ten days. The measurements were performed with AxSym assays from Abbott Laboratories. The elimination of both total and free prostate-specific antigen followed a biphasic kinetics. In the fast phase, the average of the individual elimination half-lives of total and free prostate-specific antigen amounted to 6.3 h (SD = 6.1 h; range: 0.55 to 37.1 h) and 0.57 h (SD = 0.18 h; range: 0.22 to 0.89 h), respectively. In the slow phase, total prostate-specific antigen disappeared with an average half-life of 85.6 h (SD = 11 h; range: 47.2 to 261.7 h) and free prostate-specific antigen with an average half-life of 14.4 h (SD = 10.4 h; range: 2.4 to 30.3 h). These results might be significant for the use of free and total prostate-specific antigen and its ratio as a diagnostic and prognostic tool.
对11例局限性前列腺癌患者行耻骨后根治性前列腺切除术后，研究了血清总前列腺特异性抗原和游离前列腺特异性抗原在10天疗程中的消除动力学。在手术前、手术结束后即刻、前列腺切除术后1、2、3、4、5、6小时以及随后的10天内每天采集一次样本。使用雅培实验室的AxSym检测法进行测量。总前列腺特异性抗原和游离前列腺特异性抗原的消除均遵循双相动力学。在快速阶段，总前列腺特异性抗原和游离前列腺特异性抗原的个体消除半衰期平均值分别为6.3小时（标准差=6.1小时；范围：0.55至37.1小时）和0.57小时（标准差=0.18小时；范围：0.22至0.89小时）。在缓慢阶段，总前列腺特异性抗原消失的平均半衰期为85.6小时（标准差=11小时；范围：47.2至261.7小时），游离前列腺特异性抗原消失的平均半衰期为14.4小时（标准差=10.4小时；范围：2.4至30.3小时）。这些结果对于将游离和总前列腺特异性抗原及其比值用作诊断和预后工具可能具有重要意义。
