前列腺根治切除术后前列腺特异性抗原的生物学半衰期

Biological half-life of prostate-specific antigen after radical prostatectomy.

作者信息

van Straalen J P, Bossens M M, de Reijke T M, Sanders G T

机构信息

Department of Clinical Chemistry, Academical Medical Centre, Amsterdam, The Netherlands.

出版信息

Eur J Clin Chem Clin Biochem. 1994 Feb;32(2):53-5. doi: 10.1515/cclm.1994.32.2.53.

DOI:10.1515/cclm.1994.32.2.53

PMID:7516193

Abstract

The disappearance pattern of prostate-specific antigen from serum after a standard radical prostatectomy was studied in eight patients with cancer confined to the prostate. The results were used to plot an elimination curve and calculate the best fit. A biphasic pattern was found with an average biological half-life of 1.63 hours in the alpha-phase, and 4.63 days in the beta-phase. Based on these results it is concluded that determination of prostate-specific antigen concentrations less than one month after a standard radical prostato-vesiculectomy has no value for the detection or exclusion of residual malignant processes.

摘要

对8例局限于前列腺的癌症患者进行了标准根治性前列腺切除术后血清中前列腺特异性抗原消失模式的研究。结果用于绘制消除曲线并计算最佳拟合值。发现呈双相模式，α相的平均生物半衰期为1.63小时，β相为4.63天。基于这些结果得出结论，在标准根治性前列腺膀胱切除术后不到一个月测定前列腺特异性抗原浓度对检测或排除残留恶性病变没有价值。