Leighton S E, Kay R, Leung S F, Woo J K, Van Hasselt C A
Department of Surgery, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong.
Clin Otolaryngol Allied Sci. 1997 Aug;22(4):350-4. doi: 10.1046/j.1365-2273.1997.00025.x.
The effect of irradiation for nasopharyngeal carcinoma on auditory brainstem responses and hearing was investigated in 19 otologically normal patients undergoing standard fractionated megavoltage radiotherapy. Auditory brainstem responses and pure tone audiometry were performed before radiotherapy, and at 3 and 12 months after completion of radiotherapy. There were no significant changes in the wave I-III and III-V interpeak intervals, or in sensorineural hearing thresholds (bone conduction at 4 kHz and average of bone conduction at 0.5, 1, 2 and 4 kHz), after radiotherapy. In contrast to previous studies, we found no evoked potential evidence of subclinical brainstem damage arising from irradiation for nasopharyngeal carcinoma.
对19例耳部正常且正在接受标准分割兆伏放疗的鼻咽癌患者，研究了鼻咽癌放疗对听性脑干反应和听力的影响。在放疗前、放疗结束后3个月和12个月进行了听性脑干反应和纯音听力测定。放疗后，I-III波和III-V波峰间期以及感音神经性听力阈值（4kHz骨导以及0.5、1、2和4kHz骨导平均值）均无显著变化。与先前的研究不同，我们未发现鼻咽癌放疗引起亚临床脑干损伤的诱发电位证据。
