Lau S K, Wei W I, Sham J S, Choy D T, Hui Y
Department of Surgery, Queen Mary Hospital, University of Hong Kong.
J Laryngol Otol. 1992 Oct;106(10):887-92. doi: 10.1017/s002221510012119x.
A prospective study of the effect of radiotherapy for nasopharyngeal carcinoma on hearing was carried out on 49 patients who had pure tone, impedance audiometry and auditory brain stem evoked response (ABR) recordings before, immediately, three, six and 12 months after radiotherapy. Fourteen patients complained of intermittent tinnitus after radiotherapy. We found that 11 initially normal ears of nine patients developed a middle ear effusion, three to six months after radiotherapy. There was mixed sensorineural and conductive hearing impairment after radiotherapy. Persistent impairment of ABR was detected immediately after completion of radiotherapy. The waves I-III and I-V interpeak latency intervals were significantly prolonged one year after radiotherapy. The study shows that radiotherapy for nasopharyngeal carcinoma impairs hearing by acting on the middle ear, the cochlea and the brain stem auditory pathway.
对49例鼻咽癌患者进行了一项前瞻性研究，观察放疗对听力的影响。这些患者在放疗前、放疗即刻、放疗后3个月、6个月和12个月均进行了纯音、声阻抗测听及听性脑干反应（ABR）检查。14例患者放疗后主诉间歇性耳鸣。我们发现，9例患者的11只初为正常的耳朵在放疗后3至6个月出现了中耳积液。放疗后存在混合性感音神经性和传导性听力损害。放疗结束后即刻检测到ABR持续受损。放疗1年后，I-III波和I-V波峰间期明显延长。该研究表明，鼻咽癌放疗通过作用于中耳、耳蜗及脑干听觉通路损害听力。
